ESTIMATION OF COMMUNITY-WIDE MULTI-CHEMICAL EXPOSURE VIA WATER-BASED CHEMICAL MINING: KEY RESEARCH GAPS DRAWN FROM A COMPREHENSIVE MULTI-BIOMARKER MULTI-CITY DATASET

Estimation of community-wide multi-chemical exposure via water-based chemical mining: Key research gaps drawn from a comprehensive multi-biomarker multi-city dataset

This paper explores the strong potential of chemical mining of wastewater for markers of community-wide intake of wide-ranging harmful chemicals belonging to several usage groups: industrial chemicals, personal care products, pesticides, illicit drugs, lifestyle chemicals and prescription pharmaceuticals as a proxy for multi-chemical community-wide

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FACILITATING THE INVOLVEMENT OF COMMUNITY LEADERS IN THE DEVELOPMENT OF CULTURE-BASED EDUCATION IN MAPPI DISTRICT, SOUTH PAPUA PROVINCE

This research analyzed the strategic role of community leaders in developing culture-based education and formulating General Health a social facilitation model for community leaders in improving quality education in Mappi Regency, Papua.This is a qualitative action research.Data collection used Focus Group Discussions (FGD) and data analysis used S

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Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.

BackgroundHIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases.We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophages.We also found that HI

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Understanding global changes of the mouse brain proteome after vaginal infection with HSV-2 using a label-free shotgun approach

Herpes simplex virus type 2 (HSV-2) is a common human pathogen that establishes lifelong latency in neurons of the nervous system.The number of severe central nervous system infections caused by the virus has increased recently.However, the pathogenesis of HSV-2 infection in the nervous system is not fully understood.Here, we demonstrated global pr

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